Description 
The main ingredient of Deflox is Ciprofloxacin which is a broad spectrum antibiotic of fluoroquinolone group. The bactericidal action of Ciprofloxacin results from interference with the enzyme DNA gyrase needed for synthesis of bacterial DNA. It is also effective against those bacteria which are resistant to Penicillins, Cephalosporins and Aminoglycosides.
Composition
Deflox-500 Tablet: Each film coated tablet contains Ciprofloxacin USP 500 mg as Ciprofloxacin Hydrochloride.
Deflox-750 Tablet: Each film coated tablet contains Ciprofloxacin USP 750 mg as Ciprofloxacin Hydrochloride.
Deflox-DS Suspension: Each 5 ml suspension contains Ciprofloxacin USP 250 mg as Ciprofloxacin Hydrochloride.
Indication
Deflox (Ciprofloxacin USP) is used in the treatment of infections caused by sensitive organisms.
Respiratory tract infections: Lobar and bronchopneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis.
Ear, nose & throat infections: Otitis media, sinusitis, mastoiditis, tonsillitis.
Urinary tract infections: Cystitis, urethritis, pyelonephritis, prostatitis.
Skin & soft tissue infections: Infection of wound, abscess, cellulitis, furunculosis, impetigo, infected burn.
Acute systemic infections: Septicemia, bacterimia, peritonitis.
Gastrointestinal infections: Enteric fever, diarrhea due to infection, bacillary dysentery, enteritis, peritonitis.
Eye infection: Bacterial conjunctivitis.
Infections of bone & bone joints: Osteomyelitis, septic arthritis.
Gonorrhea: Urethral, rectal and pharyngeal gonorrhea, gonorrhea caused by beta lactamase secreting organisms.
Dosage and administration
The dose of Deflox is determined according to the type of infection, severity, sensitivity of the pathogen and age, weight, and effectiveness of kidney of the patients.
Adult: Normal adult dose: 250-750 mg twice daily.
For the treatment of gonorrhea 250 mg is used as a single dose. 
Depending on the severity of urinary tract infection the dose is 250-500 mg twice daily.  
Depending on the severity of respiratory tract infection the dose is 250-750 mg twice daily.
Cystic fibrosis: In pseudomonal infection of the lower tract, the normal dose is 750 mg twice daily.
In the majority of infection, 250-500 mg twice daily should be administered. In severe infections, particularly due to Pseudomonas, Staphylococci and Streptococci, the higher dosage 750 mg twice daily should be used.
Impaired renal function: Dosage adjustments are required in patients with severe renal impairment (serum creatinine > 256 micromole/liter or creatinine clearance < 20 ml/min.) Adjustment is achieved by reducing the total daily dose by half, although monitoring of drug serum levels provides the most reliable basis for dose adjustment.
Elderly: Although higher Ciprofloxacin serum levels are found in the elderly, no adjustment of dosage is necessary.
Child: Children and adolescents (1-17 years): 10-30 mg/kg/day twice daily.
Duration of treatment: For acute infections the usual treatment period is 5 to 10 days with Ciprofloxacin. Generally treatment should be continued for at least 3 days after the sign and symptoms of the infection have been disappeared.
Side effects
Side-effects of Deflox include nausea, vomiting, abdominal pain, diarrhea, head-ache, dizziness, rash, itching, fatigue, pain of joints, mild light sensitivity, crystalurea, temporary disturbance of liver enzymes and myalgia etc.
Contraindication
Deflox should not be given to the patients with a history of hypersensitivity to Ciprofloxacin and to the other quinolones. 
Precaution 
It should be used with caution in patients with suspected or known CNS disorders such as arteriosclerosis or epilepsy or other factors which predispose to seizures and convulsions. The patients taking Deflox should drink a large quantity of water or other liquid to prevent excess alkalinity in urine. 
Drug interaction
Magnesium Hydroxide or Aluminum Hydroxide containing antacids decrease the absorption of Ciprofloxacin. The use of Ciprofloxacin with Theophylline may increase the plasma concentration of Theophylline.
Use in pregnancy and lactation 
There is no adequate and well-controlled study in pregnant women. Ciprofloxacin is excreted in human breast milk. 
Pharmaceutical precaution
Store in a cool, dry place below 30°C and protect from light. Keep out of reach of children.
Packing
Deflox-500 Tablet: Box containing 3 x 10 tablets in blister pack.
Deflox-750 Tablet: Box containing 5 x 4 tablets in blister pack.
Deflox-DS Suspension: Amber glass bottle containing dry granules for the preparation of 60 ml suspension.