Indications
Levofloxacin is demonstrated for the treatment of mellow, direct and serious contaminations caused by helpless strains of the assigned micro-organisms within the condition recorded below: Acute maxillary sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis. Acute bacterial compounding of persistent bronchitis due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis. Community-acquired pneumonia due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae. Uncomplicated & complicated urinary tract diseases due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus. Acute pyelonephritis caused by Escherichia coli. Uncomplicated & complicated skin and delicate tissue diseases counting abscesses, cellulitis, furuncles, impetigo, pyoderma, wound diseases.

Pharmacology
Levofloxacin may be a engineered, broad-spectrum, third generation fluoroquinolone anti-microbial. Chemically, Levofloxacin could be a chiral fluorinated carboxyquinolone. Levofloxacin applies antibacterial activity by repressing bacterial topoisomerase IV and DNA gyrase, the proteins required for DNA replication, translation repair and recombination. It has in vitro action against a wide run of gm-ve and gm+ve microorganisms.

Dosage & Administration
Adults:

• Acute sinusitis: 500 mg once daily for 10-14 days, or 750 mg once daily for 5 days
• Exacerbation of chronic bronchitis: 500 mg once daily for 7 days, or 750 mg once daily for 3 days (Uncomplicated), 750 mg once daily for 5 days (Complicated)
• Community-acquired pneumonia: 500 mg once daily for 7-14 days, or 750 mg once daily for 5 days
• Uncomplicated urinary-tract infections: 250 mg once daily for 3 days
• Complicated urinary-tract infections and acute pyelonephritis: 250 mg once daily for 7-10 days
• Uncomplicated skin and soft-tissue infections: 500 mg once daily for 7-10 days.
• Complicated skin and soft-tissue infections: 750 mg once daily for 7-14 days.
• Enteric fever: 500 mg once daily for 7-14 days.
• Diarrhea, cholera, shigellosis & enteritis: Mild to moderate case: 500 mg (single dose). Moderate to sever case: 500 mg once daily for 3 days

Children:

• Children 6 months to <5 years: 10 mg/kg every 12 hours.
• Children >5 years: 10 mg/kg every 24 hours

In each case, sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.

Instructions for the Use of Levofloxacin Infusion-

• Check the container for minute leaks by squeezing the inner bag firmly. If leaks are found, or if the seal is not intact, discard the solution.
• Do not use if the solution is cloudy or a precipitate is present.
• Do not use flexible containers in series connections.
• Close flow control clamp of administration set.
• Remove cover from port at bottom of container.
• Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated.
• Suspend container from hanger.
• Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Levoxin Injection.
• Open flow control clamp to expel air from set. Close clamp.
• Regulate rate of administration with flow control clamp.

Interaction
No quinolone ought to be co-administered with any arrangement containing multivalent cations, e.g., magnesium, through the same intravenous line. Stomach settling agents, Press and Adsorbents decrease assimilation of Levofloxacin. NSAID may increment the hazard of CNS incitement. Warfarin may increment the chance of dying.

Contraindications
Levofloxacin is contraindicated in patients with a history of hypersensitivity to levofloxacin, quinolone antimicrobial agents, or any other components of this product.

Side Effects
Levofloxacin is for the most part well endured. In any case, some side-effects can more often than not be seen. There's a chance of retinal separation. Other side-effects incorporate: sickness, heaving, the runs, abdominal pain, tooting and uncommon event of phototoxicity (0.1%). Side-effects which will be seen exceptionally seldom incorporate tremors, misery, uneasiness, disarray etc.

Pregnancy & Lactation
Levofloxacin isn't prescribed for utilize amid pregnancy or nursing, as the impacts on the unborn child or nursing newborn child are obscure.

Precautions & Warnings
The taking after measures ought to be taken amid organization of Levofloxacin: Levofloxacin Infusion ought to as it were be managed by moderate intravenous implantation over a period of 60 or 90 minutes depending on the dosage. While administrating Levofloxacin, satisfactory sum of water ought to be taken to maintain a strategic distance from concentrated shape of urine. Dose alteration ought to be worked out amid Levofloxacin organization in nearness of renal lacking.

Therapeutic Class
4-Quinolone preparations

Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.