Indications
Montelukast Sodium is shown for: Prophylaxis and constant treatment of asthma Acute avoidance of Exercise-Induced Bronchoconstriction (EIB) Relief of side effects of Unfavorably susceptible Rhinitis (AR): Regular & Perpetual Unfavorably susceptible Rhinitis

Pharmacology
Montelukast could be a specific and orally dynamic leukotriene receptor enemy that restrains the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are items of arachidonic corrosive digestion system and are discharged from different cells, counting pole cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been connected with the pathophysiology of asthma & unfavorably susceptible rhinitis, counting aviation route edema, smooth muscle withdrawal, and changed cellular movement related with the fiery prepare, which contribute to the signs and indications of asthma.

Dosage & Administration

Adults & adolescents (15 years & older)-

• Asthma & Allergic Rhinitis: 10 mg/day 
• Exercise-Induced Bronchoconstriction: 10 mg/day

Pediatric patients (6 to 14 years)-

• Asthma & Allergic Rhinitis: 5 mg/day 
• Exercise-Induced Bronchoconstriction: 5 mg/day

Pediatric patients (6 months to 5 years)-

• Asthma & Allergic Rhinitis: 4 mg/day 
• Exercise-Induced Bronchoconstriction: Not recommended

Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. For prevention of Acute prevention of Exercise-Induced Bronchoconstriction, a single dose should be taken at least 2 hours before exercise.

Interaction
With medication: No dosage alteration is required when montelukast is co-administered with theophylline, prednisone, prednisolone, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative-hypnotics, non-steroidal anti-inflammatory operators, benzodiazepines, decongestants, verbal contraceptives, and Cytochrome P450 (CYP) protein inducers. With nourishment and others: Bioavailability and other conditions were not altogether watched with nourishment & other conditions.

Contraindications
Montelukast is contraindicated in patients who are hypersensitive to any component of this product.

Side Effects
Common: The runs, fever, gastrointestinal distress, cerebral pain, sickness, spewing, skin responses, upper respiratory tract infection. Uncommon: Akathisia, uneasiness, arthralgia, asthenia, unusual behavior, misery, discombobulation, tiredness, dry mouth, drain, crabbiness, disquietude, muscle complaints, oedema, seizure, anomalous sensation, rest disorders. Rare: Angioedema, concentration impeded, confusion, eosinophilic granulomatosis with polyangiitis, erythema nodosum, visualization, hepatic disarranges, memory misfortune, palpitations, aspiratory eosinophilia, self-destructive propensities, tremor.

Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. Montelukast should be used during pregnancy only if clearly needed. Montelukast is excreted in breast milk. So caution should be exercised when Montelukast is given to a nursing mother.

Precautions & Warnings
Montelukast isn't indicated for utilize within the inversion of bronchospasm in intense asthma assaults, counting status asthmatic. Neuropsychiatric occasions counting disturbance, antagonistic vibe, anxiousness, discouragement, confusion, unsettling influence in consideration, dream variations from the norm, mental trips, sleep deprivation, peevishness, memory disability, eagerness, somnambulism, self-destructive considering and behavior (counting suicide) and tremor.

Therapeutic Class
Leukotriene receptor antagonists

Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.