Indications
Gliclazide is indicated for the treatment of maturity onset diabetes mellitus (NIDDM) patients who require oral hypo-glycaemic drug.

Pharmacology
Gliclazide could be a moment era sulfonylurea sedate that has hypoglycaemic and possibly valuable hematological properties. It invigorates the discharge of affront from pancreatic β-cells by encouraging Ca+2 transport over the β-cell films and diminishes hepatic glucose yield.

Dosage & Administration
Film coated tablet: The usual initial dose is 40 to 80 mg daily. The dose can be increased upto 320 mg daily in divided doses when needed. The drug should be taken before meal. For children Gliclazide is not used because it is contraindicated in juvenile-onset diabetes.

Modified release preparation: The usual daily dosage for Gliclazide 30 mg is 1 to 4 tablets & Gliclazide 60 mg is 1 to 2 tablets per day as a single dose. It is recommended that the drug should be taken at breakfast time. It is preferable to take this drug before breakfast in order to avoid or to minimize the possible onset of digestive disorders.

Interaction

The hypoglycaemic impacts of Gliclazide may be expanded by Headache medicine, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal operators and Monoamine Oxidase inhibitors. The hypoglycaemic impact of Gliclazide a few times may be diminished by Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic drugs and every so often Liquor.

Contraindications
Gliclazide ought to not be utilized in - Juvenile-onset (type-1) diabetes Diabetes related with Ketosis Diabetic patients experiencing surgery, after serious damage or amid infection Patients having touchiness for sulfonylurea bunch of drugs Pregnant ladies and breast-feeding mother Hepatic lacking.

Side Effects
There may be hypoglycaemia in concurrent conditions such as hepatic and renal infection, ailing health, liquor inebriation. Now and then migraine, gastrointestinal upsets, queasiness, discombobulation, skin responses counting hasty, pruritus, erythema may happen.

Pregnancy & Lactation
Gliclazide is contraindicated in pregnant women. It should not be used in breast feeding mother.

Precautions & Warnings
Gliclazide ought to be utilized carefully in patients with hepatic impedance. In case there's clear hepatic infection at that point gliclazide ought to not be utilized. Gliclazide can be utilized securely in patients with renal lacking because it is broadly metabolized. Gliclazide has less sudden hypoglycaemic scene than other sulfonylurea bunch of drugs.

Therapeutic Class
Sulfonylureas

Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.