Indications
Vitamin B1, B6 & B12 is demonstrated for the treatment of vitamin B1, B6 & B12 insufficiency disorder. It is additionally shown for the strong treatment of neuritis & non-inflammatory illnesses of the nerves, e.g.- Diabetic neuropathy Peripheral neuralgin Lumbago Myalgia Optic neuritis Sciatica Facial neuralgia Intercostal neuralgia Spinal torment.

Pharmacology
Vitamin B1 changes over carbohydrates, greasy acids and amino acids into vitality, advances solid nerves, moves forward temperament, reinforces the heart. Vitamin B6 shapes RBCs, makes a difference cells to create proteins, fabricates neurotransmitters e.g. serotonin and discharges put away shapes of vitality, makes a difference to avoid CVS infections and stroke, makes a difference to lift misery and facilitates a sleeping disorder. Vitamin B12 is fundamental for cell replication and vital for RBC generation, avoids iron deficiency, makes a difference to anticipate misery, decreases nerve torment, deadness, shivering and brings down the hazard of heart infections.The vitamin fixings are ingested well in per verbal gathering. It is broadly disseminated to most tissues and shows up in breast drain. Inside the cell, thiamine is generally show as diphosphate. Thiamine isn't put away to any appreciable degree within the body and sums in excess of the body’s necessities are excreted within the pee as unaltered thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are promptly ingested from the GIT taking after verbal organization and are changed over to the dynamic shapes of pyridoxal phosphate an pyridoxamine phosphate. They are put away primarily in liver where there's oxidation to 4-pyridoxic corrosive and other dormant metabolites, which are excreted in pee. As the measurements increments, relatively more prominent sums are excreted unaltered within the pee.

Dosage & Administration
Tablet: 1-3 Tablets per day or as advised by the physician.

Injection:

• In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
• In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.

Use in children: There is no information on the use of this drug in children.

 

Contraindications
Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa treatment, and in patients with extreme touchiness to any of the fixings of the arrangement.

Side Effects
By and large well endured but unfavorably susceptible responses may be watched in few cases.

Pregnancy & Lactation
Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy & lactation.

Precautions & Warnings
Cyanocobalamin ought to not be given in patients with subacute degeneration of the spinal line. Cyanocobalamin isn't appropriate shape of vitamin B12 for the treatment of optic neuropathies related with raised plasma concentrations of cyanocobalamin.

Therapeutic Class
Specific combined vitamin preparations

Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.