Composition
Each film coated tablet contains Flupentixol Dihydrochloride BP equivalent to Flupentixol 0.5 mg and Melitracen Hydrochloride INN equivalent to Melitracen 10 mg

Description
Valium Plus consists of two well known & well proven compounds: Flupentixol Dihydrochloride BP and Melitracen Hydrochloride INN. Flupentixol is a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and Melitracen is a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties.

Indication
It is indicated in various types of anxiety, depression and apathy.

Dosage and administration
Dose for Adult: The usual doses are two tablets daily, morning and noon. In severe case the morning dose may be increased to two tablets. 
Elderly: In elderly patients the dose is one tablet in the morning. Maintenance dose: Usually one tablet in the morning. In cases of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended.
Children: The tablet is not recommended for pediatric use.
Or, as directed by the physician.

Contraindication
Valium Plus is contraindicated in patients with known hypersensitivity to   Flupentixol and/or Melitracen.

Side effects
In the recommended doses side-effects are rare. These could be transient restlessness and insomnia.

Precautions
If previously the patient has been treated with tranquilizers with Valium Plus these should be withdrawn gradually.

Use in pregnancy & lactation    
It should preferably not be given during pregnancy and lactation.

Drug interactions
Flupentixol-Melitracen may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crisis. 

Pharmaceutical precautions
Store below 250C and protect from light and moisture. Keep out of reach of children.

Packing
Each box contains 5 x10 tablets in blister pack.